MTHFR C677 T gene polymorphism in lymphoproliferative diseases
نویسندگان
چکیده
منابع مشابه
Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677-->T transition in the MTHFR gene.
Angiotensin I-converting enzyme (ACE), which plays an important role in blood pressure regulation, and methylenetetrahydrofolate reductase (MTHFR) involved in homocysteine metabolism belong to a large group of polypeptides which may be potential risk factors for atherosclerosis and coronary artery disease (CAD). To assess whether polymorphisms of the genes encoding these peptides are associated...
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Background: It is believed that environmental and genetic factors may be responsible for autism. Methylenetetrahydrofolate reductase (MTHFR) and its gene polymorphisms have been shown to be implicated as risk factors in autism. Objectives: To analyze MTHFR C677T polymorphism (rs1801133) in autistic patients. Materials and Methods: This study was carried out in 2014 and 2015 in northern Ir...
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Hyperhomocysteinemia, MTHFR 677C3T Polymorphism, and Stroke To the Editor: We welcome the report from Madonna and co-workers examining the role of prothrombotic and homocysteine (Hcy) pathway polymorphisms in risk of ischemic stroke in young adults.1 We wish to comment on several issues raised by their article relating to the design of studies of genetic risk factors for complex phenotypes such...
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Homocysteine is an emerging new risk factor for cardiovascular disease. It is a thiol compound derived from methionine and involved in two main metabolic pathways: the cycle of activated methyl groups, requiring folate and vitamin B12 as cofactors, and the transsulfuration pathway to cystathionine and cysteine requiring vitamin B6 as cofactor. The homocysteine metabolism represents an interesti...
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By Henrik Griesser, Douglas Tkachuk, Marciano D. Reis, and Tak W. Mak L YMPHOID LEUKEMIAS and malignant lymphomas are neoplasms characterized by the proliferation of cells derived from the lymphoid tissue and its precursors. Like other malignant hematological disorders, the majority of these lymphoid malignancies are of monoclonal origin.’ Although clonality does not necessarily correlate with ...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2006
ISSN: 0887-8013,1098-2825
DOI: 10.1002/jcla.20103